Mechanistic modeling of the dynamics of microbiological and ecotoxicological pressures on transboundary water bodies using active monitoring of sentinel species.

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Dr Mélissa PALOS LADEIRO
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The objective of the postdoctoral fellowship is to conduct in situ experiments on the caging of aquatic organisms and to participate in the measurement of biomarkers associated with immunotoxicity and reproductive toxicity. In addition, the candidate will contribute to the development of a toxicokinetic (TK) model for this species (if possible, a physiologically based (PBK) model) which will be used to analyze the bioaccumulation data obtained in situ. For this purpose, should historical data prove insufficient, additional kinetic data encompassing multiple time points may need to be generated under controlled conditions. This TK model could be coupled with a toxicodynamic (TD) model to analyze the time–dose–response relationships of biomarkers associated with immunotoxicity.

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