Soumis par assosefa le mer 29/12/2021 - 09:49
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Résumé

The development of the use of plastics during the twentieth century has led to the appearance
of a new type of pollutant: microplastics. These microplastics, with a very long half-life, are
small debris (<5mm) resulting from the degradation of plastics in the environment. These
particles are widely distributed in the world's fresh and salt waters, at concentrations that can
exceed several thousand per m3, and can be easily ingested and accumulate in the tissues of
aquatic organisms, leading to toxic effects.
Using zebrafish raised in standard or gnotobiotic conditions as a model, this project aims to
determine (i) whether microplastics, alone or in combination with commensal bacteria, can
affect the gut microbiota and/or immunity of fish at the larval stage, (ii) what are the molecular
and immunological mechanisms involved, and (iii) whether early exposure to these particles
can affect the immune status and commensal microbiota of fish in the long term.

Type d'offre