Soumis par assosefa le lun 23/03/2020 - 09:56
ineris
Modelling of the Adverse Outcome Pathway (AOP) leading to fecundity inhibition in zebrafish : from initiating events to population impacts
Résumé

The main objective of the thesis project will therefore be the development and improvement of multi-scale models of toxicity pathways enabling more accurate predictions of EDCs impacts on the populations.

The PhD project strategy will follow 4 steps: (i) application of the zebrafish PBPK model to the chemicals studied, (ii) improvement of the existing model for steroid hormone dynamics (or model) (HPG axis model), (iii) translation of the oocyte dynamic model from fathead minnow to zebrafish, (iv) prediction of the chemicals’ impact on population dynamic.

Deadline : 20/05/2020

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Type d'offre